CGDB Gene Information

Tag Content
CGDB ID CGD-OvA-022197
Uniprot Accession W5QC67; W5QC67; W5QC67_SHEEP
Protein Name Uncharacterized protein
Gene Name PER1
Ensembl Information ENSOART00000020594; ENSOARP000000203
Organism Ovis aries
NCBI Taxa ID 9940
Circadian Information
Evidence Phase Amplitude
(FOLD)		 Sentence Tissue/Cell Data type PMID
Peak Trough External
condition
Small-scale ZT 4 ZT 0 LD 5.00 The 24-h rhythmic expression of clock genes (Rev-erbalpha, Per1, Per2, Bmal1, and Cry1) in the suprachiasmatic nucleus and PT reflected the ambient photoperiod/melatonin signal and not the changing physiology. SCN Small-scale [1]
Small-scale ZT 0 ZT 12 LD 2.00 High-amplitude Bmal1, Clock, Nr1d1, Cry2 and Per3 mRNA rhythms were apparent in skeletal muscle, which were phase advanced by up to 3.5 h 2 days after phase shift, whereas Per1 expression was downregulated at this time. Pparα, Pgc1α and Nampt mRNA were constitutively expressed in both conditions. muscle Small-scale [1]
Protein Sequence
(Fasta)		 MSRSGPLEGA DGGGDPRPGE PFCPGGGPSP GPPEHRPCPG PSLADDTDAN SNGSSGNESN 60
GPESRGASQR SSHSSSSGNG KDSALLETTE SSKSTNSQSP SPPSSSIAYS LLSASSEPDN 120
PSTSGCSSEQ SARARTQKEL MTALRELKLR LPPERRGKGR SGTLATLQYA LACVKQVQAN 180
QEFYQQWSLE EGEPCAMDMS TYTLEELEHV TSEYTLRNQD TFSVAVSFLT GRIVYISEQA 240
GVLLRCKRDV FRGVRFSELL APQDVGVFYG STTPSRLPTW GPGASAGSDL KDFTQEKSVF 300
CRIRGGPDRD PGPRYQPFRL TPYVTKIRVS DGAPAQPCCL LIAERIHSGY EAPRIPPDKR 360
IFTTRHTPSC LFQDVDERAA PLLGYLPQDL LGAPVLLFLH PEDRPLMLAI HKKILQLAGQ 420
PFDHSPIRFC ARNGEYVTMD TSWAGFVHPW SRKVAFVLGR HKVRTAPLNE DVFTPPAPSP 480
TLSLDSDIQE LSEQIHRLLL QPVHSPSPTG LCGVGPVPSS GPLLSPGSSS DSNGGDAEGP 540
GPPAPVTFQQ ICKDVHLVKH QGQQLFIESR ARPLTRPRVP ATGTFKVKTL PCQSPELEAA 600
LAPIQAPVAL AAEEAERKEA SSCSYQQINC LDSILRYLES CNLPGTAKRK CASSSSCTAS 660
SASDDDKQRA GPVSVGAKKD PSAVLPGEGA TPLKEPVVGG GALSPLALAN KAESVVSVTS 720
QCSFSSTIVH VGDKKPPESD IIMMEDLPSL PPGPAPSPAP SPTVAPDPAP DAYRPVGLTK 780
AVLSLHTQKE EQAFLSRFRD FSRLRGLDSS STAPSAPGER GCHHSPATPG RRHHCRSKAK 840
RSRHHQTARA EAPSYISQPS PVPPSAPWPP PPATPPFPAV VQPYPLPVFP PRGSPQPLPP 900
APTSVPPAAF SAPLVTPMVA LVLPNYLFPT PSTYPYGAPQ TPAEGSPPPA SRSPSPSLPP 960
LPPSPPHRPN SPLFNSRCSS PLQLNLLQLE EPPRGEGGAA AGGSGSSAGP PPPSEETVEP 1020
EARLAEVTES SNQDALSGSS DLLELLLQED SRSGTGSAAS GSLASGLGSG SGSHEGGSTS 1080
ASIPRSSQSS HTSKYFGSID SSEAEAGAAQ ARAEPGDQVI KYVLQDPIWL LMANADQRVM 1140
MTYQVPSRSR DMASVLKQDR ERLRAMQKQQ PRFSEDQRRE LGAVHSWVRK GQLPRALDVM 1200
ACVDCGSSTQ EPGHPDDPLF SEVDGLGLEP MEEGGGEGGG GGGEGEGSSG AQAQAADTSR 1260
AVTREGEEKG GTPPCPAFPA TENGTS 1286
Sequence Source Uniprot/ENA
Orthology
CGDB IDSpieces IdentityE-ValueScore
CGD-AiM-053758Ailuropoda melanoleuca67.03 0.00e+00 1165.2
CGD-AnP-031610Anas platyrhynchos41.45 0.00e+00 818.1
CGD-AnC-055229Anolis carolinensis59.03 0.00e+00 862.4
CGD-AsM-064219Astyanax mexicanus44.55 0.00e+00 750
CGD-BoT-054337Bos taurus65.42 0.00e+00 1560
CGD-CaJ-048018Callithrix jacchus61.13 0.00e+00 1442.2
CGD-CaF-064770Canis familiaris61.11 0.00e+00 1416
CGD-CaP-029122Cavia porcellus62.6 0.00e+00 1337
CGD-ChS-031205Chlorocebus sabaeus61.22 0.00e+00 1454.9
CGD-DaR-072764Danio rerio43.92 0.00e+00 874.4
CGD-DaN-031719Dasypus novemcinctus62.69 0.00e+00 1433.3
CGD-DiO-053613Dipodomys ordii60.2 0.00e+00 1407.1
CGD-DrM-071117Drosophila melanogaster32.29 2.40e-27 121.7
CGD-EqC-020994Equus caballus61.22 0.00e+00 1429.5
CGD-ErE-072203Erinaceus europaeus62.07 0.00e+00 1337
CGD-FeC-031667Felis catus59.54 0.00e+00 1369
CGD-FiA-064838Ficedula albicollis40.6 0.00e+00 808.1
CGD-GaM-021007Gadus morhua45.89 0.00e+00 651.7
CGD-GaG-021834Gallus gallus40.37 0.00e+00 791.2
CGD-GaA-060790Gasterosteus aculeatus42.97 0.00e+00 897.5
CGD-GoG-062877Gorilla gorilla65.49 0.00e+00 1508.8
CGD-HoS-021038Homo sapiens (Human)64.68 0.00e+00 1476.1
CGD-IcT-062043Ictidomys tridecemlineatus64.27 0.00e+00 1459.1
CGD-LaC-070172Latimeria chalumnae58.11 0.00e+00 748
CGD-LeO-033639Lepisosteus oculatus44.76 0.00e+00 966.1
CGD-LoA-069322Loxodonta africana65.2 0.00e+00 1533.9
CGD-MaM-031836Macaca mulatta61.13 0.00e+00 1446.4
CGD-MaE-058204Macropus eugenii49.34 9.00e-137 485.3
CGD-MeT-071723Medicago truncatula26.32 2.50e+00 31.57
CGD-MeL-041695Melampsora laricipopulina26.76 1.85e-01 33.11
CGD-MiM-059459Microcebus murinus78.02 0.00e+00 796.2
CGD-MoD-062809Monodelphis domestica60.05 0.00e+00 1383.2
CGD-MuM-031636Mus musculus (Mouse)64.35 0.00e+00 1453
CGD-MuP-028062Mustela putorius furo59.06 0.00e+00 1355.1
CGD-MyL-066363Myotis lucifugus65.07 0.00e+00 1505
CGD-NoL-039781Nomascus leucogenys65.17 0.00e+00 1473.4
CGD-OcP-070087Ochotona princeps61.86 0.00e+00 1372.1
CGD-OrN-042393Oreochromis niloticus51.03 0.00e+00 674.1
CGD-OrA-038635Ornithorhynchus anatinus41.33 0.00e+00 846.3
CGD-OrC-049700Oryctolagus cuniculus59.27 0.00e+00 1352.4
CGD-OrL-058700Oryzias latipes42.8 0.00e+00 892.9
CGD-OtG-066239Otolemur garnettii59.16 0.00e+00 1384.4
CGD-PaT-040966Pan troglodytes63.7 0.00e+00 1439.5
CGD-PaA-057182Papio anubis55.28 0.00e+00 889.4
CGD-PeS-059572Pelodiscus sinensis41 0.00e+00 805.8
CGD-PoF-059832Poecilia formosa55.11 0.00e+00 732.3
CGD-PoA-067892Pongo abelii78.07 0.00e+00 716.8
CGD-PrC-056290Procavia capensis65.25 0.00e+00 1153.3
CGD-PtV-028552Pteropus vampyrus61.85 0.00e+00 1223.4
CGD-PyT-028299Pyrenophora triticirepentis29.17 6.69e-01 31.57
CGD-RaN-021793Rattus norvegicus66.48 0.00e+00 1514.6
CGD-SaH-069946Sarcophilus harrisii61.96 0.00e+00 1394
CGD-SoA-065078Sorex araneus67.1 0.00e+00 1551.2
CGD-SuS-066161Sus scrofa62.94 0.00e+00 1420.6
CGD-TaG-066410Taeniopygia guttata40.69 0.00e+00 798.5
CGD-TaR-050668Takifugu rubripes45 0.00e+00 891.7
CGD-TaS-048703Tarsius syrichta60.11 0.00e+00 1327.4
CGD-TeN-071576Tetraodon nigroviridis46.97 0.00e+00 949.9
CGD-TrV-027738Trichoderma virens32 1.50e+00 30.03
CGD-TuB-071737Tupaia belangeri80.74 0.00e+00 690.6
CGD-TuT-061692Tursiops truncatus75.43 0.00e+00 1201
CGD-XeT-049391Xenopus tropicalis53.4 0.00e+00 740.7
CGD-XiM-048808Xiphophorus maculatus45.22 0.00e+00 956.8
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0031490--F:chromatin DNA binding
GO:0070888--F:E-box binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000989--F:transcription factor activity, transcription factor binding
GO:0032922--P:circadian regulation of gene expression
GO:0097167--P:circadian regulation of translation
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0043966--P:histone H3 acetylation
GO:0070932--P:histone H3 deacetylation
GO:0043967--P:histone H4 acetylation
GO:2000323--P:negative regulation of glucocorticoid receptor signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042634--P:regulation of hair cycle
GO:0002028--P:regulation of sodium ion transport
GO:0051591--P:response to cAMP
Interpro

IPR000014--PAS
IPR013655--PAS_fold_3
IPR022728--Period_circadian-like_C
PROSITE

PS50112--PAS
Pfam

PF08447--PAS_3
PF12114--Period_C
SMART

SM00091--PAS