CGDB Gene Information

Tag Content
CGDB ID CGD-MiM-059459
Ensembl Accession ENSMICP00000012524.1
Protein Name PER1
Ensembl Information ENSMICG00000013724; ENSMICT00000013728
Organism Microcebus murinus
NCBI Taxa ID 30608
Circadian Information
Phase Amplitude
(FOLD)		 Tissue/Cell Evidence
Peak Trough External
condition
ZT 12 ZT 0 LD >10 Predicted from orthologs Q65ZG8
CT 0 CT 12 DD2 5.8 gluteal muscles Predicted from orthologs F7AU00
ZT 4 ZT 21 LD 2 human HaCaT keratinocytes Predicted from orthologs O15534
CT 0 CT 12 DD2 4 U2OS cells Predicted from orthologs O15534
ZT 0 ZT 12 LD 2 muscle Predicted from orthologs W5QC67
ZT 4 ZT 0 LD 5 SCN Predicted from orthologs W5QC67
ZT 12 ZT 0 LD 30 abdominal adipose tissue Predicted from orthologs Q8CHI5
ZT 20 ZT 8 LD 11 basolateral nucleus of the amygdala Predicted from orthologs Q8CHI5
CT 12 CT 20 DD17 6.25 colon Predicted from orthologs Q8CHI5
ZT 18 ZT 6 LD 2 decidua Predicted from orthologs Q8CHI5
ZT 4 ZT 16 LD 3.5 entral nucleus of the amygdala Predicted from orthologs Q8CHI5
ZT 20 ZT 8 LD 8 hippocampus Predicted from orthologs Q8CHI5
ZT 9 ZT 0 LD 48 intestinal jejunal mucosa Predicted from orthologs Q8CHI5
CT 12 CT 0 DD17 16.67 liver Predicted from orthologs Q8CHI5
ZT 16 ZT 4 LD >5 mammary gland (pubescent female F344 rats) Predicted from orthologs Q8CHI5
ZT 4 ZT 16 LD 8 nucleus accumbens core Predicted from orthologs Q8CHI5
ZT 20 ZT 8 LD 7 nucleus accumbens shell Predicted from orthologs Q8CHI5
CT 20 CT 0 DD1 1.71 PC12 cell Predicted from orthologs Q8CHI5
ZT 0 ZT 16 LD 7.5 prefrontal cortex Predicted from orthologs Q8CHI5
ZT 4 ZT 16 LD 3 SCN Predicted from orthologs Q8CHI5
ZT 20 ZT 8 LD 15 SCN Predicted from orthologs Q8CHI5
ZT 4 ZT 20 LD 3 SCN Predicted from orthologs Q8CHI5
ZT 8 ZT 0 LD 4.76 uteri Predicted from orthologs Q8CHI5
ZT 8 ZT 20 LD 7 ventral tegmental area Predicted from orthologs Q8CHI5
Descriptionperiod circadian clock 1 [Source:HGNC Symbol;Acc:HGNC:8845](View all)
Protein Sequence
(Fasta)		 MSGPLEGADG GGDPRPGESF CPGGVPSPGP PQHWPCPGPS PADDTDANSN GSSGNESNGH 60
ESRGASQRSS HSSSSGNGKD SALLETTESS KSTNSQSPSP PSSSIAYSLL SASSEQDNPS 120
TSGCSSEQSA RARTQKELMT ALRELKLRLP PERRGKGRSG TLATLQYALA CVKQVQANQE 180
YYQQWSLEEG EPCAMDMSTY TLEELEHITS EYTLRNQDTF SVAVSFLTGR IVYISEQAGV 240
LLRCRDVFRG ARFSELLAPQ DVGVFYGSTA PSRLPTWGTG ALAGSGLKDF TQEKSVFCRI 300
RGGPDRDPGP RYQPFRLTPY VTKIRVSDGT PAQPCCLLIA ERIHSGYEAP RIPPDKRIFT 360
TRHTPSCLFQ DVDERAAPLL GYLPQDLLGA PVLLFLHPED RPLMLAIHKK ILQLAGQPFD 420
HSPIRFCARN GEYVTMDTSW AGFVHPWSRK VAFVLGRHKV RTAPLNEDVF TPPAPSPAPS 480
LDTDIQDLSE QIHRLLLQPV HSPSPTGLCG VGPVTSPGPL HSPGSSSDSN GGDAEGPGPP 540
APXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 600
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXAS 660
SASDDDKQRT GPVSVGTKKD PSSEVLSGEG ATPQKEPVVG GTLSPLTLAN KAESVVSVTS 720
QCSFSSTIVH VGDKKPPESD IIMMEDLPGL APGPAPSPAP SPTVAPDPAP DAYRPVGLTK 780
AVLSLHTQKE EQAFLSRFRD LGRLRGLDSS STAPSAPGER GCHHGPAPPG RRHHCRSKAK 840
RSRHHQTPRA EAPCYISHPS PVPPSAAWPP PPATTPFPAV VQPYPFPVFS PRGGPQPLPP 900
APTSVPPATF PAPLVTPMVA LVLPNYLFSA PSGYPYGAPQ TPTEGPLTPA PTXXXXXXXX 960
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 1020
XXXXXGEVTE SSNQDALSGS SDLLELLLQE DSRSGTGSAA SGSLGSGLGS GSGSGSHEGG 1080
STSASITRDS QSSHTSKYFG SVDSSEAEAG AAQARAEPGD QVIKYVLQDP IWLLMANADQ 1140
HVMMTYQVPS RDMTSVLKQD RERLRAMQKQ QPRFSEDQRR ELGAVHSWVR KGQLPQALDV 1200
MACVDCGSSA QDPGHPDDPL FSELDGLGLE PMEEGGGEGG SGGGGGG 1247
Nucleotide Sequence
(Fasta)		 ATGAGCGGTC CCCTAGAAGG GGCTGATGGG GGAGGGGACC CCAGGCCGGG GGAATCCTTT 60
TGTCCTGGAG GGGTCCCATC CCCAGGGCCT CCACAGCACT GGCCTTGCCC GGGCCCCAGC 120
CCGGCCGATG ACACTGATGC CAACAGCAAT GGCTCAAGCG GCAATGAATC CAACGGGCAT 180
GAATCCAGGG GTGCATCTCA ACGGAGCTCA CATAGTTCCT CCTCTGGCAA TGGCAAGGAC 240
TCAGCCCTTC TGGAGACCAC TGAGAGCAGC AAGAGCACAA ACTCTCAGAG CCCATCCCCA 300
CCCAGCAGTT CCATTGCCTA CAGCCTCCTA AGTGCCAGCT CGGAGCAGGA CAACCCGTCT 360
ACCAGTGGCT GCAGCAGTGA GCAGTCAGCC CGGGCAAGGA CCCAGAAGGA ACTCATGACA 420
GCACTTCGGG AGCTCAAGCT TCGACTGCCG CCAGAGCGCC GGGGCAAGGG CCGCTCTGGG 480
ACTCTGGCCA CGCTACAGTA CGCACTGGCC TGTGTCAAAC AGGTGCAGGC CAATCAGGAA 540
TACTACCAGC AGTGGAGCCT GGAAGAGGGT GAGCCTTGTG CCATGGACAT GTCCACCTAC 600
ACGCTGGAGG AGCTGGAGCA CATAACATCT GAGTACACGC TTCGCAACCA GGATACCTTC 660
TCGGTGGCTG TCTCCTTCCT GACAGGCCGA ATTGTCTACA TTTCGGAGCA AGCGGGTGTC 720
CTGCTGCGTT GCCGGGATGT GTTCCGGGGT GCCCGCTTCT CAGAGCTCCT GGCTCCCCAG 780
GATGTGGGCG TCTTTTATGG TTCCACAGCC CCATCTCGCC TGCCCACCTG GGGCACTGGG 840
GCCTTGGCAG GTTCAGGCCT CAAGGACTTC ACCCAGGAGA AGTCTGTCTT CTGCCGTATC 900
AGAGGAGGCC CTGACCGGGA TCCAGGGCCT CGGTACCAGC CATTCCGCCT AACCCCATAT 960
GTGACCAAGA TCCGGGTTTC AGATGGGACC CCTGCGCAGC CATGCTGCCT GCTCATTGCA 1020
GAGCGCATCC ACTCCGGTTA TGAAGCTCCC CGGATCCCCC CCGACAAGAG GATATTCACT 1080
ACGCGGCACA CACCCAGCTG CCTCTTCCAG GATGTGGATG AAAGGGCTGC CCCACTGCTG 1140
GGCTATCTGC CCCAGGACCT CCTGGGGGCC CCAGTGCTCC TATTCCTGCA TCCTGAGGAC 1200
CGACCCCTCA TGTTGGCCAT CCACAAGAAG ATCCTGCAGC TGGCAGGCCA GCCCTTTGAC 1260
CACTCCCCTA TCCGCTTCTG TGCCCGTAAC GGGGAGTATG TGACTATGGA CACCAGCTGG 1320
GCTGGATTTG TACACCCCTG GAGCCGCAAG GTGGCCTTTG TGTTGGGTCG ACACAAAGTA 1380
CGCACGGCAC CCCTGAATGA GGATGTCTTC ACACCCCCAG CCCCCAGCCC AGCTCCGTCC 1440
CTGGACACTG ATATCCAGGA CCTGTCAGAG CAGATCCACC GGCTGCTGTT GCAGCCTGTG 1500
CACAGCCCCA GCCCCACAGG GCTCTGTGGA GTTGGCCCTG TGACATCCCC AGGTCCCCTG 1560
CACAGCCCAG GCTCTTCCAG TGATAGCAAT GGGGGTGATG CTGAGGGGCC TGGGCCTCCC 1620
GCCCCGNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 1680
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 1740
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 1800
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 1860
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 1920
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNCGGCCTCC 1980
TCCGCCTCTG ACGATGACAA GCAGAGGACA GGTCCAGTCT CTGTGGGGAC CAAGAAAGAT 2040
CCTTCGTCGG AAGTGCTGTC TGGGGAGGGG GCCACTCCTC AGAAGGAGCC AGTGGTGGGA 2100
GGCACCCTGA GCCCGCTCAC CCTGGCCAAT AAGGCGGAGA GCGTGGTGTC CGTCACCAGT 2160
CAGTGTAGCT TCAGCTCCAC CATCGTCCAT GTGGGAGACA AGAAGCCCCC GGAGTCGGAC 2220
ATCATCATGA TGGAGGACCT TCCTGGCCTA GCCCCAGGCC CAGCCCCCAG CCCGGCCCCC 2280
AGCCCCACAG TAGCCCCTGA CCCAGCCCCA GATGCCTACC GTCCAGTGGG CCTGACCAAG 2340
GCCGTGCTGT CCCTGCACAC ACAGAAGGAA GAGCAAGCCT TCCTCAGTCG TTTCCGGGAC 2400
CTTGGCAGGC TGCGTGGACT CGACAGCTCT TCCACGGCCC CCTCCGCCCC TGGTGAGCGA 2460
GGCTGCCACC ATGGCCCTGC ACCCCCCGGC CGCCGACACC ACTGCCGATC CAAAGCCAAG 2520
CGCTCACGCC ACCACCAGAC CCCCCGGGCC GAAGCCCCCT GCTACATCTC CCACCCATCA 2580
CCTGTGCCAC CCTCTGCTGC CTGGCCCCCC CCACCAGCCA CTACCCCCTT CCCAGCCGTG 2640
GTCCAACCCT ACCCCTTCCC AGTATTCTCC CCTCGAGGAG GCCCTCAGCC TCTTCCCCCT 2700
GCACCCACTT CTGTGCCCCC TGCCACTTTC CCTGCCCCCC TGGTAACCCC AATGGTGGCC 2760
TTAGTGCTCC CTAACTATCT GTTCTCTGCC CCATCCGGCT ATCCCTACGG GGCACCCCAG 2820
ACCCCAACGG AGGGGCCTCT TACCCCTGCT CCCACNNNNN NNNNNNNNNN NNNNNNNNNN 2880
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 2940
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 3000
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 3060
NNNNNNNNNN NNNNNGGGGA GGTAACAGAG TCCTCCAATC AGGACGCACT TTCTGGCTCC 3120
AGTGACCTGC TGGAACTGCT ACTGCAAGAG GACTCTCGCT CTGGCACGGG CTCTGCAGCC 3180
TCAGGCTCCC TGGGCTCTGG CTTGGGCTCT GGGTCTGGTT CAGGCTCCCA CGAAGGGGGC 3240
AGCACCTCAG CCAGCATCAC TCGTGACAGT CAGAGCAGCC ACACAAGCAA GTACTTCGGC 3300
AGCGTAGACT CTTCTGAGGC TGAGGCTGGG GCTGCTCAGG CCAGGGCTGA GCCCGGGGAC 3360
CAAGTCATTA AGTACGTGCT CCAGGATCCC ATCTGGTTGC TCATGGCCAA CGCTGACCAA 3420
CATGTCATGA TGACTTACCA GGTGCCCTCC AGGGACATGA CCTCTGTGCT AAAGCAGGAC 3480
CGGGAGCGGC TCCGGGCCAT GCAGAAACAG CAGCCTCGGT TCTCAGAGGA CCAGCGTCGG 3540
GAACTGGGTG CTGTGCACTC CTGGGTCCGG AAGGGCCAGC TGCCTCAGGC CCTTGATGTC 3600
ATGGCCTGTG TGGACTGTGG TAGCAGTGCA CAAGACCCTG GCCACCCTGA TGACCCACTG 3660
TTCTCAGAGC TGGATGGACT GGGGCTGGAG CCCATGGAGG AGGGCGGAGG CGAGGGGGGA 3720
AGTGGTGGTG GTGGTGGTGG T 3741
Sequence Source Ensembl
Orthology
CGDB IDSpieces IdentityE-ValueScore
CGD-CaE-021686Caenorhabditis elegans26.01 2.10e-14 78.95
CGD-EqC-020994Equus caballus77.03 0.00e+00 783.1
CGD-HoS-021038Homo sapiens (Human)79.26 0.00e+00 813.5
CGD-OvA-022197Ovis aries78.02 0.00e+00 796.2
CGD-RaN-021793Rattus norvegicus78.83 0.00e+00 807.7
Gene Ontology

GO:0005515--protein binding
GO:0097167--circadian regulation of translation
GO:0043153--entrainment of circadian clock by photoperiod
GO:0009416--response to light stimulus
GO:2000323--negative regulation of glucocorticoid receptor signaling pathway
GO:0042752--regulation of circadian rhythm
GO:0002028--regulation of sodium ion transport
GO:0031490--chromatin DNA binding
GO:0000976--transcription regulatory region sequence-specific DNA binding
GO:0032922--circadian regulation of gene expression
GO:0051591--response to cAMP
GO:0007623--circadian rhythm
GO:0019900--kinase binding
GO:0070932--histone H3 deacetylation
GO:0010608--posttranscriptional regulation of gene expression
GO:0043966--histone H3 acetylation
GO:0000989--transcription factor activity, transcription factor binding
GO:0000122--negative regulation of transcription from RNA polymerase II promoter
GO:0045892--negative regulation of transcription, DNA-templated
GO:0008134--transcription factor binding
GO:0045944--positive regulation of transcription from RNA polymerase II promoter
GO:0005634--nucleus
GO:0070888--E-box binding
GO:0042634--regulation of hair cycle
GO:0043967--histone H4 acetylation
GO:0031625--ubiquitin protein ligase binding
GO:0000978--RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0005737--cytoplasm