CGDB Gene Information

Tag Content
CGDB ID CGD-TuB-071737
Ensembl Accession ENSTBEP00000003664.1
Protein Name PER1
Ensembl Information ENSTBEG00000004202; ENSTBET00000004235
Organism Tupaia belangeri
NCBI Taxa ID 37347
Circadian Information
Phase Amplitude
(FOLD)		 Tissue/Cell Evidence
Peak Trough External
condition
ZT 12 ZT 0 LD >10 Predicted from orthologs Q65ZG8
CT 0 CT 12 DD2 5.8 gluteal muscles Predicted from orthologs F7AU00
ZT 4 ZT 21 LD 2 human HaCaT keratinocytes Predicted from orthologs O15534
CT 0 CT 12 DD2 4 U2OS cells Predicted from orthologs O15534
ZT 0 ZT 12 LD 2 muscle Predicted from orthologs W5QC67
ZT 4 ZT 0 LD 5 SCN Predicted from orthologs W5QC67
ZT 12 ZT 0 LD 30 abdominal adipose tissue Predicted from orthologs Q8CHI5
ZT 20 ZT 8 LD 11 basolateral nucleus of the amygdala Predicted from orthologs Q8CHI5
CT 12 CT 20 DD17 6.25 colon Predicted from orthologs Q8CHI5
ZT 18 ZT 6 LD 2 decidua Predicted from orthologs Q8CHI5
ZT 4 ZT 16 LD 3.5 entral nucleus of the amygdala Predicted from orthologs Q8CHI5
ZT 20 ZT 8 LD 8 hippocampus Predicted from orthologs Q8CHI5
ZT 9 ZT 0 LD 48 intestinal jejunal mucosa Predicted from orthologs Q8CHI5
CT 12 CT 0 DD17 16.67 liver Predicted from orthologs Q8CHI5
ZT 16 ZT 4 LD >5 mammary gland (pubescent female F344 rats) Predicted from orthologs Q8CHI5
ZT 4 ZT 16 LD 8 nucleus accumbens core Predicted from orthologs Q8CHI5
ZT 20 ZT 8 LD 7 nucleus accumbens shell Predicted from orthologs Q8CHI5
CT 20 CT 0 DD1 1.71 PC12 cell Predicted from orthologs Q8CHI5
ZT 0 ZT 16 LD 7.5 prefrontal cortex Predicted from orthologs Q8CHI5
ZT 4 ZT 16 LD 3 SCN Predicted from orthologs Q8CHI5
ZT 20 ZT 8 LD 15 SCN Predicted from orthologs Q8CHI5
ZT 4 ZT 20 LD 3 SCN Predicted from orthologs Q8CHI5
ZT 8 ZT 0 LD 4.76 uteri Predicted from orthologs Q8CHI5
ZT 8 ZT 20 LD 7 ventral tegmental area Predicted from orthologs Q8CHI5
Descriptionperiod circadian clock 1 [Source:HGNC Symbol;Acc:HGNC:8845](View all)
Protein Sequence
(Fasta)		 ETTESSKSTN SQSPSPPSSS IAYSLLSASS EQDNPSTSGC SSEQSARART QKELMTALRE 60
LKLRLPPERR GKGRSGTLAT LQYALACVKQ VQANQEYYQQ WSLEEGEPCA MDMSTYTLEE 120
LEHITSEYTL RNQDTFSVAV SFLTGRIVYI SEQAGVLLRC KRDVFRGARF SELLAPQDVG 180
VFYGSTAPSR LPTWGTGASA GSGLKDFTQE KSVFCRIRGG PDRDPGPRYQ PFRLTPYVTK 240
IRVSDGAPAQ PCCLLIAERI HSGYEXXXXX XXXXXXXXXX XXXXXFQDVD ERAAPLLGYL 300
PQDLLGAPVL LFLHPEDRPL MLAIHKKILQ LAGQPFDHSP IRFCARNGEY VTMDTSWAGF 360
VHPWSRKVAF VLGRHKVRTA PLNEDVFTPP APSPALSLDP DIQELSEQIH RLLLQPCHSP 420
RTSGLCGVGP VTSPGPLHSP GSXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 480
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXAPS QAPLTSAPEE GERKEASSCS 540
YQQINCLDSI LRYLESCNIP STTKRKCASS SSYTASSASD DDKQRTGSVP LGAKKDPSSA 600
VLPGEGATPR KEPVVGGTLS PLTLANKAES VVSVTSQCSF SSTIVHVGDK KPPESXXXXX 660
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 720
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXHPSPVPP 780
SAPWPPPPAT TPFPAVVQPY SLPVFSPRGG SQPLPPAPTS VPPAAFPAPL VTPMVALVLP 840
NYLFPTPSSY PYGVPQPPAE GPPTPASYSP SPSLPPLPPS PPHHPDSPLF NSRCSSPLQL 900
NLLQLEELPR AEGGAIAGGP GSNAGPPPPN EEAAEPEARL VEVTESSNQD ALSGSSDLLE 960
LLLQEDSRSG TGSAASGSLG SGLGSGSGSG SHEGGSTSAS ITRDSQSSHT SKYFGSIDSS 1020
EAEAGAARAR AEPGDQVIKY VLQDPIWLLM ANADQRVMMT YQVPSRDMAS VLKQDRERLR 1080
AMQKQQPRFS EDQRRELGAV HSWVRKGQLP RALDVV 1116
Nucleotide Sequence
(Fasta)		 GAAACCACTG AGAGCAGCAA GAGTACAAAC TCTCAGAGCC CATCTCCACC CAGCAGTTCC 60
ATTGCCTATA GCCTTCTGAG TGCCAGCTCG GAGCAGGACA ATCCGTCCAC CAGTGGCTGC 120
AGTAGTGAAC AGTCAGCCCG GGCAAGAACC CAGAAAGAGC TCATGACAGC ACTTCGAGAG 180
CTTAAGCTTC GACTGCCACC AGAGCGTCGG GGCAAGGGTC GCTCTGGGAC CCTGGCCACA 240
CTCCAGTATG CACTGGCCTG TGTTAAGCAG GTGCAAGCCA ATCAGGAGTA CTACCAGCAG 300
TGGAGCCTGG AGGAGGGTGA GCCGTGTGCC ATGGATATGT CCACCTACAC TTTGGAGGAG 360
CTGGAGCACA TCACATCTGA ATACACACTT CGCAACCAGG ACACTTTCTC TGTGGCTGTC 420
TCCTTCCTGA CGGGCCGAAT TGTCTACATC TCAGAGCAGG CAGGTGTCCT GCTTCGCTGC 480
AAGCGGGATG TGTTCCGAGG TGCCCGCTTC TCAGAGCTCC TGGCTCCTCA AGATGTGGGC 540
GTCTTCTATG GTTCCACTGC CCCATCTCGC CTGCCCACCT GGGGCACTGG GGCCTCAGCA 600
GGTTCAGGCC TGAAGGACTT CACCCAGGAG AAGTCTGTCT TCTGCCGTAT CAGAGGAGGT 660
CCTGATCGGG ATCCAGGGCC TCGGTACCAG CCATTCCGTC TGACCCCCTA TGTGACCAAG 720
ATCCGGGTCT CAGATGGGGC TCCTGCACAG CCGTGTTGCC TGCTCATCGC TGAGCGCATT 780
CATTCGGGTT ATGAAGNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 840
NNNNNNNNNN NNNNTTTCCA GGATGTGGAT GAAAGGGCTG CCCCGCTGTT GGGCTACCTG 900
CCCCAGGACC TCCTGGGGGC CCCAGTGCTC CTGTTCCTGC ATCCTGAGGA CCGACCTCTC 960
ATGCTAGCCA TCCACAAGAA GATTCTGCAG CTGGCAGGTC AGCCCTTTGA CCACTCCCCT 1020
ATCCGGTTCT GTGCCCGGAA TGGGGAGTAT GTCACCATGG ACACCAGCTG GGCTGGCTTC 1080
GTGCACCCCT GGAGCCGCAA GGTGGCCTTT GTGCTGGGCC GCCACAAAGT ACGCACGGCG 1140
CCCCTGAATG AAGACGTATT TACCCCTCCG GCCCCCAGCC CAGCTCTGTC CCTGGACCCC 1200
GATATCCAGG AGCTCTCCGA GCAGATCCAC CGGCTACTGT TGCAGCCCTG TCACAGCCCC 1260
AGGACCTCCG GGCTCTGTGG GGTCGGCCCT GTGACGTCCC CAGGCCCTCT CCACAGTCCT 1320
GGCTCCNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 1380
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 1440
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 1500
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNC TGCTCCAAGC 1560
CAGGCCCCGC TAACCTCGGC CCCTGAAGAG GGTGAGAGGA AAGAAGCTTC CAGCTGCTCC 1620
TACCAGCAGA TTAATTGCCT AGACAGCATC CTCAGGTACC TGGAGAGCTG CAACATCCCT 1680
AGCACCACGA AGCGGAAGTG TGCCTCCTCT TCTTCCTACA CCGCCTCCTC AGCCTCTGAC 1740
GATGACAAGC AGCGAACGGG TTCAGTCCCT CTGGGGGCCA AGAAAGATCC GTCGTCAGCA 1800
GTGCTGCCTG GGGAGGGGGC CACCCCGCGG AAGGAGCCAG TGGTGGGAGG CACTCTGAGC 1860
CCGCTCACCC TGGCCAATAA GGCAGAGAGC GTGGTGTCCG TCACCAGTCA GTGTAGCTTC 1920
AGCTCCACCA TCGTCCATGT GGGAGACAAG AAGCCCCCGG AGTCGGNNNN NNNNNNNNNN 1980
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 2040
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 2100
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 2160
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 2220
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 2280
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNC ACCCCTCACC CGTGCCGCCT 2340
TCTGCCCCCT GGCCACCCCC ACCAGCTACC ACCCCCTTCC CTGCTGTGGT CCAGCCCTAC 2400
TCCCTCCCAG TGTTCTCCCC CCGAGGAGGC TCCCAGCCTC TTCCCCCAGC CCCTACATCT 2460
GTGCCCCCTG CTGCTTTCCC TGCCCCCCTG GTAACCCCAA TGGTGGCCTT GGTACTCCCT 2520
AATTATCTGT TCCCTACCCC ATCCAGCTAT CCTTATGGGG TACCCCAGCC CCCTGCAGAA 2580
GGGCCTCCTA CCCCTGCCTC CTATTCGCCT TCTCCGTCCC TGCCTCCTCT GCCCCCCAGT 2640
CCCCCTCACC ACCCAGACTC TCCACTATTC AACTCGAGAT GTAGCTCCCC GCTCCAGCTC 2700
AATCTGCTGC AGCTTGAGGA GCTCCCCCGT GCTGAGGGGG GTGCCATTGC AGGTGGCCCT 2760
GGGAGCAATG CTGGGCCCCC ACCTCCCAAT GAGGAGGCTG CTGAGCCAGA GGCCAGACTG 2820
GTGGAGGTAA CTGAGTCCTC CAACCAGGAT GCGCTGTCCG GCTCCAGTGA CCTGCTGGAG 2880
CTGCTGCTGC AAGAGGACTC TCGCTCTGGC ACAGGCTCTG CAGCTTCGGG CTCCCTGGGC 2940
TCTGGCTTGG GCTCTGGGTC TGGTTCCGGC TCCCATGAAG GGGGCAGCAC GTCAGCCAGC 3000
ATCACCCGTG ACAGCCAGAG CAGCCACACA AGCAAGTACT TTGGCAGCAT CGACTCCTCC 3060
GAGGCTGAGG CTGGGGCTGC TCGGGCCAGG GCTGAGCCCG GAGACCAGGT CATTAAGTAC 3120
GTGCTCCAGG ATCCCATCTG GCTACTCATG GCCAACGCTG ACCAGCGTGT CATGATGACC 3180
TACCAGGTGC CCTCCAGGGA CATGGCGTCA GTGCTGAAGC AGGACCGGGA GCGACTTCGG 3240
GCCATGCAGA AGCAGCAGCC ACGGTTCTCA GAGGACCAGC GGCGGGAGCT GGGTGCAGTG 3300
CACTCCTGGG TCCGGAAGGG CCAACTGCCT CGGGCCCTCG ATGTGGTG 3348
Sequence Source Ensembl
Orthology
CGDB IDSpieces IdentityE-ValueScore
CGD-CaE-021686Caenorhabditis elegans29.9 1.40e-09 62.77
CGD-EqC-020994Equus caballus80.18 0.00e+00 682.2
CGD-HoS-021038Homo sapiens (Human)81.02 0.00e+00 693.7
CGD-OvA-022197Ovis aries80.74 0.00e+00 690.6
CGD-RaN-021793Rattus norvegicus81.67 0.00e+00 697.2
Gene Ontology

GO:0005737--cytoplasm
GO:0000978--RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0031625--ubiquitin protein ligase binding
GO:0007623--circadian rhythm
GO:0043967--histone H4 acetylation
GO:0032922--circadian regulation of gene expression
GO:0042634--regulation of hair cycle
GO:0070888--E-box binding
GO:0019900--kinase binding
GO:0043966--histone H3 acetylation
GO:0005634--nucleus
GO:0005515--protein binding
GO:0045944--positive regulation of transcription from RNA polymerase II promoter
GO:0008134--transcription factor binding
GO:0045892--negative regulation of transcription, DNA-templated
GO:0000122--negative regulation of transcription from RNA polymerase II promoter
GO:0000989--transcription factor activity, transcription factor binding
GO:0010608--posttranscriptional regulation of gene expression
GO:0070932--histone H3 deacetylation
GO:0051591--response to cAMP
GO:0000976--transcription regulatory region sequence-specific DNA binding
GO:0031490--chromatin DNA binding
GO:0002028--regulation of sodium ion transport
GO:0042752--regulation of circadian rhythm
GO:2000323--negative regulation of glucocorticoid receptor signaling pathway
GO:0009416--response to light stimulus
GO:0043153--entrainment of circadian clock by photoperiod
GO:0097167--circadian regulation of translation