CGDB Gene Information

Tag Content
CGDB ID CGD-OrC-049700
Ensembl Accession ENSOCUP00000017727.1
Protein Name PER1
Ensembl Information ENSOCUG00000026333; ENSOCUT00000022715
Organism Oryctolagus cuniculus
NCBI Taxa ID 9986
Circadian Information
Phase Amplitude
(FOLD)		 Tissue/Cell Evidence
Peak Trough External
condition
ZT 12 ZT 0 LD >10 Predicted from orthologs Q65ZG8
CT 0 CT 12 DD2 5.8 gluteal muscles Predicted from orthologs F7AU00
ZT 4 ZT 21 LD 2 human HaCaT keratinocytes Predicted from orthologs O15534
CT 0 CT 12 DD2 4 U2OS cells Predicted from orthologs O15534
ZT 0 ZT 12 LD 2 muscle Predicted from orthologs W5QC67
ZT 4 ZT 0 LD 5 SCN Predicted from orthologs W5QC67
ZT 12 ZT 0 LD 30 abdominal adipose tissue Predicted from orthologs Q8CHI5
ZT 20 ZT 8 LD 11 basolateral nucleus of the amygdala Predicted from orthologs Q8CHI5
CT 12 CT 20 DD17 6.25 colon Predicted from orthologs Q8CHI5
ZT 18 ZT 6 LD 2 decidua Predicted from orthologs Q8CHI5
ZT 4 ZT 16 LD 3.5 entral nucleus of the amygdala Predicted from orthologs Q8CHI5
ZT 20 ZT 8 LD 8 hippocampus Predicted from orthologs Q8CHI5
ZT 9 ZT 0 LD 48 intestinal jejunal mucosa Predicted from orthologs Q8CHI5
CT 12 CT 0 DD17 16.67 liver Predicted from orthologs Q8CHI5
ZT 16 ZT 4 LD >5 mammary gland (pubescent female F344 rats) Predicted from orthologs Q8CHI5
ZT 4 ZT 16 LD 8 nucleus accumbens core Predicted from orthologs Q8CHI5
ZT 20 ZT 8 LD 7 nucleus accumbens shell Predicted from orthologs Q8CHI5
CT 20 CT 0 DD1 1.71 PC12 cell Predicted from orthologs Q8CHI5
ZT 0 ZT 16 LD 7.5 prefrontal cortex Predicted from orthologs Q8CHI5
ZT 4 ZT 16 LD 3 SCN Predicted from orthologs Q8CHI5
ZT 20 ZT 8 LD 15 SCN Predicted from orthologs Q8CHI5
ZT 4 ZT 20 LD 3 SCN Predicted from orthologs Q8CHI5
ZT 8 ZT 0 LD 4.76 uteri Predicted from orthologs Q8CHI5
ZT 8 ZT 20 LD 7 ventral tegmental area Predicted from orthologs Q8CHI5
Descriptionperiod circadian clock 1 [Source:HGNC Symbol;Acc:HGNC:8845](View all)
Protein Sequence
(Fasta)		 MSGPLEGADG GGDPRPGESF CPDGVPSPGP PQHRPRSHSS SSGNGKDSAL LETTESSKST 60
NSQSPSPPSS SIAYSLLSAS SEQDNPSTSG CSSEQSARAR TQKELMTALR ELKLRLPPER 120
RGKGRSGTLA TLQYALACVK QVQANQEYYQ QWSLEEGEPC AMDMSTYTLE ELEHITSEYT 180
LRNQDTFSVA VSFLTGRIVY ISEQAAILLR CKRDVFRGAR FSELLAPQDV GVFYGSTAPS 240
RLPTWGTGAS AGSGLKDFTQ EKSVFCRIRG GPDRDPGPRY QPFRLTPYVT KIRVSDGAPA 300
QPCCLLIAER IHSGYEAPRI PPDKRIFTTR HTPSCLFQDV DERAAPLLGY LPQDLLGAPV 360
LLFLHPEDRP LMLAIHKKIL QLAGQPFDHS PIRFCARNGE YVTMDTSWAG FVHPWSRKVA 420
FVLGRHKVRT APLNEDVFTP PAPSPALSLD PDIHELSEQI HRLLLQPVHS SSPTGLCGVG 480
PMTSPGPLHS PGSSSDSNGG DAEGPGPPAP VTFQQICKDV HLVKHQGQQL FIESRARPPP 540
RPRLPATGTF KAKALPSQSP DPELEVAPAP IQAPLALVPE EAEQKEASSC SYQQINCLDS 600
ILRYLESCNI PSTTKRKCDD DRQRAGPVPM GTKKDAAAAV LSGEGATPQK EAVVGGTLSP 660
LALANKAESV VSVTSQCSFS STIVHVGDKK PPEAGMGMEP GRSTRAPLGP QPAPSCHIIM 720
EDLPDAYRPV GLTKAVLSLH TQKEEQAFLS RFRDLGRLRR LDGSSTAPSA PGERGSHRDV 780
PEPAFCPVQD QPAPGPCLRT GPTVASPCQA GVPGCSQGSL GSGSETGRRR CCVPAPHLCP 840
LPLFPAPLVT PMVALVLPNY LFPTTSTYPY GVPQSPAEGP PTPASQSPSP SLPPLPPSPP 900
PRPDSPLFQS RCSSPLQLNL LQLEEPPRAE GAAVAGGPGS SAGPPPPSEE AAEPEARMVE 960
VTESSNQDAL SGSSDLLELL LQEDSRSGTG SAASGSLGSG LGSHEEGSTS ASITRSSQSS 1020
HTSKYFGSVD SSEAEAGAAR ARAEPGDQVI KYVLQDPIWL LMANADQRVM MTYQVPSRDV 1080
ASVLKQDRER LRAMQKQQPR FSEDQRRELG AVHSWVRKGQ LPRALDVMAC VDCGSSAQDP 1140
GHPEDPVFSE LEGLGLEPMG EEARAQGEAK VSGSQDSAME EEEQGGSSSG PALPAEENGT 1200
S 1201
Nucleotide Sequence
(Fasta)		 ATGAGTGGCC CCCTAGAAGG GGCTGATGGG GGTGGGGACC CCAGACCCGG AGAATCCTTC 60
TGTCCAGACG GGGTCCCATC CCCAGGGCCC CCACAGCACC GGCCTCGGTC ACACAGCTCT 120
TCCTCCGGCA ATGGCAAGGA CTCTGCCCTG CTGGAGACCA CGGAGAGCAG CAAGAGCACA 180
AACTCTCAGA GCCCGTCCCC ACCCAGCAGT TCCATCGCCT ATAGCCTTCT GAGTGCCAGC 240
TCAGAGCAGG ACAACCCATC CACCAGCGGC TGCAGCAGTG AACAGTCAGC CCGGGCGAGA 300
ACGCAGAAGG AACTCATGAC GGCGCTTCGG GAGCTGAAGC TTCGGCTGCC ACCAGAGCGC 360
CGGGGCAAGG GCCGCTCCGG CACGCTGGCC ACGCTGCAGT ACGCACTGGC CTGCGTGAAG 420
CAGGTGCAGG CCAACCAGGA GTACTACCAG CAATGGAGCC TGGAAGAAGG CGAGCCGTGC 480
GCCATGGACA TGTCCACCTA CACCCTGGAG GAGCTGGAGC ACATCACGTC CGAGTACACG 540
CTCCGCAACC AGGATACCTT CTCGGTGGCC GTCTCCTTCC TGACCGGCCG GATCGTGTAC 600
ATCTCGGAGC AGGCGGCCAT CCTGCTGCGT TGCAAGCGGG ACGTGTTCCG AGGTGCCCGC 660
TTCTCGGAGC TCCTGGCTCC CCAGGACGTG GGCGTTTTCT ACGGTTCCAC TGCCCCGTCT 720
CGCCTGCCCA CCTGGGGCAC GGGAGCCTCG GCAGGTTCAG GCCTCAAGGA CTTCACCCAA 780
GAGAAGTCTG TCTTCTGCCG TATCAGAGGA GGTCCTGACC GGGACCCAGG GCCTCGGTAC 840
CAGCCATTCC GCCTGACTCC GTATGTGACC AAGATCCGGG TCTCAGACGG GGCCCCCGCC 900
CAGCCGTGCT GCCTGCTCAT CGCAGAACGC ATTCACTCGG GCTATGAAGC TCCCCGAATC 960
CCTCCTGACA AGAGGATCTT CACCACGCGG CACACACCCA GCTGCCTTTT CCAGGATGTG 1020
GACGAAAGGG CTGCTCCGTT GCTGGGCTAT CTGCCCCAGG ACCTCCTCGG GGCCCCAGTG 1080
CTCCTGTTCC TGCATCCCGA GGACCGACCC CTCATGCTGG CCATCCACAA GAAGATCCTA 1140
CAGCTAGCGG GCCAGCCTTT TGACCACTCC CCTATCCGCT TCTGCGCCCG CAATGGGGAG 1200
TACGTCACCA TGGACACCAG CTGGGCCGGC TTCGTGCACC CCTGGAGCCG CAAGGTGGCC 1260
TTTGTGTTGG GCCGCCACAA AGTACGCACG GCACCCCTGA ATGAGGACGT GTTCACGCCC 1320
CCTGCTCCCA GCCCGGCTCT GTCCCTGGAC CCTGACATCC ACGAGCTGTC TGAGCAGATC 1380
CACCGGCTGC TGTTGCAGCC TGTGCACAGC TCCAGCCCCA CGGGGCTCTG TGGTGTTGGC 1440
CCCATGACGT CCCCAGGCCC CCTGCACAGC CCTGGCTCCT CCAGTGACAG CAACGGGGGC 1500
GATGCGGAAG GGCCCGGGCC TCCTGCTCCA GTGACCTTCC AGCAGATCTG CAAGGACGTG 1560
CATCTGGTGA AACACCAGGG GCAGCAGCTT TTCATTGAGT CCCGGGCCCG GCCTCCACCT 1620
CGGCCCCGCC TCCCCGCTAC AGGCACATTC AAAGCCAAGG CCCTTCCCAG CCAGTCCCCA 1680
GACCCAGAAC TGGAGGTGGC CCCTGCTCCC ATCCAGGCCC CGCTAGCCTT GGTCCCTGAG 1740
GAGGCTGAGC AGAAGGAAGC CTCCAGCTGC TCCTACCAGC AGATCAACTG CCTGGACAGC 1800
ATCCTCAGGT ACCTGGAGAG CTGCAACATC CCCAGCACAA CCAAGCGCAA GTGCGACGAT 1860
GACAGGCAGA GGGCGGGTCC AGTCCCCATG GGGACCAAGA AAGATGCGGC GGCGGCAGTG 1920
CTCTCTGGGG AGGGGGCAAC TCCGCAGAAG GAGGCGGTGG TGGGAGGCAC CCTGAGCCCG 1980
CTTGCCCTGG CCAATAAGGC AGAGAGCGTG GTGTCCGTCA CCAGCCAGTG TAGCTTCAGC 2040
TCCACCATCG TCCATGTGGG AGACAAGAAG CCCCCGGAGG CGGGTATGGG CATGGAGCCA 2100
GGGCGTAGCA CCCGGGCTCC ACTTGGTCCC CAGCCAGCCC CTTCCTGCCA CATCATCATG 2160
GAGGACCTGC CTGATGCCTA CCGCCCAGTG GGCTTGACCA AGGCCGTGCT GTCCCTGCAC 2220
ACACAGAAGG AAGAGCAAGC CTTCCTCAGC CGCTTCCGAG ACCTCGGCCG GCTGCGCAGA 2280
CTCGACGGCT CTTCCACGGC CCCCTCGGCC CCTGGCGAGC GAGGTAGCCA CCGGGATGTC 2340
CCCGAGCCTG CCTTCTGCCC AGTCCAGGAC CAGCCTGCCC CGGGGCCCTG CCTCAGGACA 2400
GGCCCCACGG TAGCCTCTCC CTGCCAGGCC GGGGTTCCTG GCTGCAGCCA GGGCAGCCTG 2460
GGGTCTGGCT CTGAGACAGG CAGGCGGAGG TGCTGTGTTC CAGCTCCACA TCTGTGCCCC 2520
CTGCCACTTT TCCCTGCCCC CCTGGTGACC CCAATGGTAG CCTTAGTGCT CCCAAACTAT 2580
CTGTTCCCCA CTACATCCAC CTATCCCTAT GGGGTGCCCC AGAGCCCTGC GGAGGGGCCT 2640
CCCACCCCTG CCTCCCAGTC TCCGTCCCCT TCCCTGCCTC CCCTGCCCCC CAGTCCCCCG 2700
CCACGTCCGG ACTCCCCACT GTTCCAGTCA AGATGTAGCT CCCCGCTCCA GCTAAACCTG 2760
CTGCAGCTTG AGGAGCCCCC CCGTGCCGAG GGGGCTGCCG TTGCAGGGGG TCCCGGGAGC 2820
AGTGCTGGGC CCCCGCCTCC CAGTGAGGAG GCCGCTGAGC CAGAGGCCAG AATGGTGGAG 2880
GTGACCGAGT CCTCCAATCA GGACGCGCTG TCTGGCTCCA GCGACCTGCT GGAGCTGCTG 2940
CTGCAGGAAG ACTCTCGCTC TGGCACCGGC TCCGCAGCCT CGGGCTCCCT GGGCTCTGGC 3000
TTAGGCTCCC ACGAAGAGGG CAGCACCTCG GCCAGCATCA CCCGCAGCAG TCAGAGCAGC 3060
CACACGAGCA AGTACTTCGG CAGCGTGGAC TCTTCAGAGG CAGAGGCTGG GGCTGCGCGG 3120
GCCAGGGCTG AGCCTGGAGA CCAGGTCATT AAGTATGTAC TCCAGGATCC CATTTGGCTG 3180
CTCATGGCCA ATGCTGACCA GCGTGTCATG ATGACCTACC AGGTGCCCTC CAGGGACGTG 3240
GCGTCCGTGC TGAAGCAGGA CCGGGAGCGG CTCCGGGCCA TGCAGAAACA GCAGCCTCGG 3300
TTTTCCGAGG ACCAGCGGCG GGAACTGGGG GCTGTGCACT CCTGGGTCCG GAAGGGCCAG 3360
CTGCCTCGGG CCCTTGATGT GATGGCCTGT GTGGACTGCG GCAGTAGCGC CCAAGACCCC 3420
GGCCACCCTG AGGACCCTGT CTTCTCGGAG CTGGAGGGAC TGGGGCTGGA GCCCATGGGT 3480
GAGGAGGCCC GGGCCCAGGG GGAGGCCAAG GTCTCCGGCT CCCAGGACTC AGCCATGGAG 3540
GAGGAGGAGC AAGGTGGGAG CTCATCCGGT CCAGCCTTAC CCGCCGAGGA AAATGGCACC 3600
AGCTAG 3606
Sequence Source Ensembl
Orthology
CGDB IDSpieces IdentityE-ValueScore
CGD-CaE-021686Caenorhabditis elegans27.82 6.40e-13 73.94
CGD-EqC-020994Equus caballus60.08 0.00e+00 1377.1
CGD-HoS-021038Homo sapiens (Human)60.7 0.00e+00 1414.4
CGD-OvA-022197Ovis aries59.27 0.00e+00 1352.4
CGD-RaN-021793Rattus norvegicus61.85 0.00e+00 1381.7
Gene Ontology

GO:0005737--cytoplasm
GO:0000978--RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0031625--ubiquitin protein ligase binding
GO:0007623--circadian rhythm
GO:0043967--histone H4 acetylation
GO:0032922--circadian regulation of gene expression
GO:0042634--regulation of hair cycle
GO:0070888--E-box binding
GO:0019900--kinase binding
GO:0043966--histone H3 acetylation
GO:0005634--nucleus
GO:0005515--protein binding
GO:0045944--positive regulation of transcription from RNA polymerase II promoter
GO:0008134--transcription factor binding
GO:0045892--negative regulation of transcription, DNA-templated
GO:0000122--negative regulation of transcription from RNA polymerase II promoter
GO:0000989--transcription factor activity, transcription factor binding
GO:0010608--posttranscriptional regulation of gene expression
GO:0070932--histone H3 deacetylation
GO:0051591--response to cAMP
GO:0000976--transcription regulatory region sequence-specific DNA binding
GO:0031490--chromatin DNA binding
GO:0002028--regulation of sodium ion transport
GO:0042752--regulation of circadian rhythm
GO:2000323--negative regulation of glucocorticoid receptor signaling pathway
GO:0009416--response to light stimulus
GO:0043153--entrainment of circadian clock by photoperiod
GO:0097167--circadian regulation of translation