CGDB Gene Information

Tag Content
CGDB ID CGD-CaE-021686
Uniprot Accession Q65ZG8; Q65ZG8; PER_CAEEL; H2L053; P91313
Protein Name Period protein homolog lin-42; Abnormal cell lineage protein 42
Gene Name lin-42; F47F6.1
Genbank Protein ID NP_001022176.1; NP_001022177.1; NP_001022178.1
Genbank Nucleotide ID NM_001027005.3; NM_001027006.4; NM_001027007.2
EMBL (Genbank) ID AAF13188.1
Organism Caenorhabditis elegans
NCBI Taxa ID 6239
Circadian Information
Evidence Phase Amplitude
(FOLD)		 Sentence Tissue/Cell Data type PMID
Peak Trough External
condition
Small-scale ZT 12 ZT 0 LD >10 Relative expression levels of lin-42 are an excellent marker of C. elegans development. Small-scale [1]
DescriptionTranscriptional repressor which interacts with the promoter region of target genes (PubMed:25032706). Has a specific role in developmental timing where it regulates temporal expression of a number of miRNAs and mRNAs (PubMed:16300753, PubMed:25032706, PubMed:25319259). Controls temporal cell fate transition during embryonic and early larval development by restricting the expression of specific miRNAs, including let-7, miR-48, lin-4, miR-35 and miR-58 (PubMed:24699545, PubMed:25032706, PubMed:25319259). Restricts the accumulation of lin-29 in the hypodermis to the larval L4 stage, thus controlling terminal differentiation of seam cells (PubMed:10550049). Has a role in the miRNA-mediated specification of asymmetric gene expression patterns in gustatory neurons (PubMed:25032706). May also regulate genes involved in other biological processes including transport, small molecule metabolism, and growth (PubMed:25032706). Inhibits dauer formation, by antagonizing daf-12 (PubMed:20843862).(View all)
Protein Sequence
(Fasta)		 MEPAGHSSAT HNIVVPNANP TQPQPLAPAM REEGATLSPP NTWSSSSVEF LDDADDNRLL 60
FTCTFTLPHG TVLSSATYAD GFHEQYLTIG DNFLARLEPK GQSFILSAAA ASVKQRIFAR 120
VTMPDGALRA CELLCEFETD RAKITVLALR SAFSLQASHV SSNFHVFTFI TKHSSTCALT 180
HIDYASIPYL GLLPTDLIGK SLLAFVYSPD VHVVRQAHID LHNSRGKIVK SIADLRLVAH 240
NGSILRCQTE WSAYVNPWTR KMELVVARHR ICSLPIGDSD VISSPPPGIQ SNTLPPVMAK 300
TFEDELRTIM NKPVPSTSRH SHHHHHSSLK DQNQGFPANI DLGAYIDKIV EQLVVNSTAQ 360
QQQKVAVAAA AAAQAAQAAV VATAQIRKVA SAPPTTSTDP PLSYTQINCL ENVHRLLKSQ 420
SRPESPAKQD EPFDEKKYPP QTPLTREALT LHTKRFEDEY KDTWCRRLKR LSDDVPSSPP 480
AKRTTPIHWT SSSQNHYRTM APAPPPPPGK NYQITYTPLD DLTDQKSTNT KSDVENVAYP 540
ISGSKFSTPM RLSIDGLLPR GATSTGGASP TSGTNSPPVF PKTSSSSSLL MLRDSQN 597
Nucleotide Sequence
(Fasta)		 ATGGAGCCAG CCGGGCACTC AAGCGCAACA CATAACATCG TTGTGCCCAA CGCCAATCCC 60
ACGCAGCCCC AACCACTTGC ACCAGCAATG CGTGAGGAAG GTGCCACGTT GTCACCCCCG 120
AACACCTGGT CCTCGTCCTC CGTAGAATTT CTGGACGACG CGGACGACAA TCGACTCTTG 180
TTCACGTGCA CCTTCACATT ACCCCACGGT ACCGTACTCT CATCTGCCAC GTATGCTGAC 240
GGATTCCACG AGCAATATTT GACGATTGGA GATAACTTTC TGGCGAGGCT AGAGCCCAAG 300
GGACAGAGCT TCATCTTGTC CGCCGCCGCC GCTTCGGTAA AGCAGAGGAT TTTTGCAAGG 360
GTTACTATGC CAGACGGAGC CCTGCGGGCC TGTGAGCTGC TTTGCGAGTT CGAGACCGAT 420
CGGGCCAAGA TCACCGTGTT GGCGTTGCGA TCGGCGTTCA GTCTTCAGGC CAGCCACGTG 480
TCATCCAACT TCCACGTCTT CACTTTCATC ACCAAGCACT CGTCGACGTG TGCTCTTACC 540
CATATTGATT ACGCCTCGAT TCCATACCTT GGTCTCCTAC CCACCGATCT CATTGGTAAA 600
TCACTGCTAG CCTTTGTCTA TTCCCCAGAT GTACATGTCG TGCGGCAGGC GCACATTGAT 660
CTTCACAACT CGCGCGGAAA GATCGTCAAA TCCATCGCCG ACCTCCGACT CGTCGCCCAC 720
AACGGATCGA TCCTCCGATG CCAGACCGAA TGGAGCGCCT ACGTGAATCC ATGGACCCGA 780
AAAATGGAGC TAGTCGTCGC CAGACACCGT ATCTGCTCCC TTCCAATCGG AGACTCGGAT 840
GTGATCTCCT CACCACCACC AGGCATCCAG TCAAACACCC TGCCACCGGT TATGGCGAAG 900
ACTTTCGAGG ATGAGCTGAG AACTATTATG AATAAGGTGA GTTCCGCTAT CTCTTCAGTA 960
ACCTTCTTAT CATCCGGCGA CGGTGCCAGT CACCGCTTAT CTTCTTCTTC AGTCCTACTT 1020
GTTTTGACGC TGCACTTTTA TCTCTGCGCC TCCTTGAGAA GAGACACCCG GCTAGCACGG 1080
AGAATTAGAC GGCGCGAGAG TGGTCAGCAG CGCCATCTCT CGGAGCAAAA AGTACACATG 1140
CTGGCACTGC GGAGCATGGC ACCATGCCAA GAGAAAGAGT GCAAGAATGA CGCTCTGGCG 1200
GGAGGAGCAG TGTCAGGTAC CACTGATGAG CTCATCCCCC GCCGCACTTT TTTGGAGTTC 1260
GCATGGAACG GGGAGTGTAA CTTCATAGGG GGACCAGTCC TATATGGGTC TCGGAGAGAT 1320
ATGGTACAGG TCCTACAAAA ACCTACAAAG TTGAAATCTT AG 1362
Sequence Source Uniprot/ENA
Orthology
CGDB IDSpieces IdentityE-ValueScore
CGD-AiM-035243Ailuropoda melanoleuca26.26 1.20e-17 89.74
CGD-AnP-031610Anas platyrhynchos23.29 1.50e-18 92.82
CGD-AnC-055229Anolis carolinensis24.26 4.70e-16 84.34
CGD-AsM-064219Astyanax mexicanus22.47 1.80e-17 89.35
CGD-BoT-071185Bos taurus28.26 2.30e-17 87.43
CGD-CaJ-041907Callithrix jacchus29.17 5.20e-15 80.88
CGD-CaF-048259Canis familiaris25.25 6.50e-19 93.59
CGD-CaP-043134Cavia porcellus24.07 1.50e-17 89.35
CGD-ChS-042175Chlorocebus sabaeus29.27 1.50e-14 79.34
CGD-ChH-042958Choloepus hoffmanni29.32 6.00e-13 73.17
CGD-DaR-072764Danio rerio24.05 1.20e-21 103.2
CGD-DaN-031719Dasypus novemcinctus27.82 5.30e-13 74.33
CGD-DiO-057828Dipodomys ordii24.68 4.30e-20 97.83
CGD-DrM-071117Drosophila melanogaster33.94 9.00e-15 80.11
CGD-EqC-040235Equus caballus25.32 1.40e-20 99.37
CGD-ErE-072203Erinaceus europaeus28.24 2.60e-12 72.02
CGD-FeC-047752Felis catus25 7.70e-17 87.04
CGD-FiA-064838Ficedula albicollis23.91 5.70e-18 90.89
CGD-GaM-064107Gadus morhua27.33 4.90e-21 100.9
CGD-GaG-021834Gallus gallus23.22 1.60e-17 89.35
CGD-GaA-060790Gasterosteus aculeatus30.14 3.20e-16 85.11
CGD-GoG-030217Gorilla gorilla24.61 1.50e-17 89.35
CGD-HoS-062136Homo sapiens (Human)28.47 6.70e-15 80.49
CGD-HoV-027716Hordeum vulgare33.33 1.95e-01 34.65
CGD-IcT-068082Ictidomys tridecemlineatus25.67 3.30e-20 98.21
CGD-LaC-028735Latimeria chalumnae23.38 3.10e-19 95.13
CGD-LeO-065998Lepisosteus oculatus27.07 3.10e-22 105.1
CGD-LoA-053612Loxodonta africana27.82 6.50e-13 73.94
CGD-MaM-031836Macaca mulatta27.17 2.10e-14 78.95
CGD-MaE-031352Macropus eugenii30.17 8.60e-14 76.64
CGD-MaP-054486Magnaporthe poae41.94 3.60e+00 30.42
CGD-MeL-042819Melampsora laricipopulina28.43 2.40e-02 36.58
CGD-MeG-072597Meleagris gallopavo23.38 2.60e-16 85.11
CGD-MiM-059459Microcebus murinus26.01 2.10e-14 78.95
CGD-MoD-067747Monodelphis domestica29.27 1.90e-14 78.95
CGD-MuM-064869Mus musculus (Mouse)27.82 2.80e-13 73.94
CGD-MuP-066925Mustela putorius furo25.59 6.40e-19 93.97
CGD-MyL-055612Myotis lucifugus23.24 3.30e-16 84.34
CGD-NoL-069268Nomascus leucogenys28.47 1.10e-14 79.72
CGD-OcP-070087Ochotona princeps26.01 2.70e-14 78.57
CGD-OrN-042393Oreochromis niloticus26.63 1.50e-16 86.27
CGD-OrA-038635Ornithorhynchus anatinus22.01 3.80e-14 78.18
CGD-OrC-049700Oryctolagus cuniculus27.82 6.40e-13 73.94
CGD-OtG-040337Otolemur garnettii24.54 2.70e-17 88.58
CGD-PaT-063745Pan troglodytes28.47 1.10e-14 79.72
CGD-PaA-041667Papio anubis28.47 1.10e-14 79.72
CGD-PeS-044679Pelodiscus sinensis21.32 1.30e-14 79.72
CGD-PoF-059832Poecilia formosa27.22 5.70e-16 84.34
CGD-PoA-060690Pongo abelii29.27 1.50e-14 79.34
CGD-PrC-056290Procavia capensis28 1.90e-15 82.42
CGD-PtV-052486Pteropus vampyrus23.53 5.70e-16 83.96
CGD-RaN-022186Rattus norvegicus23.65 3.70e-19 94.74
CGD-SaH-047243Sarcophilus harrisii29.27 1.80e-14 78.95
CGD-SoA-065078Sorex araneus26.32 7.30e-15 80.49
CGD-SuS-028663Sus scrofa24.5 3.90e-17 87.81
CGD-TaG-066410Taeniopygia guttata22.8 1.30e-17 89.74
CGD-TaR-059779Takifugu rubripes28.99 3.70e-18 91.28
CGD-TaS-050246Tarsius syrichta20.93 2.00e-13 75.48
CGD-TeN-064899Tetraodon nigroviridis28.99 1.00e-17 89.74
CGD-TuB-071737Tupaia belangeri29.9 1.40e-09 62.77
CGD-TuT-061692Tursiops truncatus28 6.90e-15 80.49
CGD-XeT-058979Xenopus tropicalis24.57 6.70e-17 87.43
CGD-XiM-036627Xiphophorus maculatus23.47 8.60e-16 83.57
Keyword

KW-0877--Alternative promoter usage
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0030154--P:cell differentiation
GO:0007275--P:multicellular organism development
GO:0061067--P:negative regulation of dauer larval development
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0040034--P:regulation of development, heterochronic
GO:0006351--P:transcription, DNA-templated
Interpro

IPR000014--PAS
SMART

SM00091--PAS