CGDB Gene Information


Tag Content
CGDB ID CGD-RaN-019438
Uniprot Accession D4ABB2; D4ABB2; D4ABB2_RAT
Protein Name Megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (Human) (Predicted)
Gene Name Mlc1; Mlc1_predicted; rCG_59299
Genbank Protein ID NP_001101575.1; XP_006242263.1
Genbank Nucleotide ID NM_001108105.1; XM_006242201.2
Organism Rattus norvegicus
NCBI Taxa ID 10116
Circadian Information
Evidence Phase Amplitude
(FOLD)
Sentence Tissue/Cell Data type PMID
Peak Trough External
condition
High-throughput ZT 18 ZT 6 LD 2.29 Genes involved in the metabolism and transport of endogenous compounds, xenobiotics, and therapeutic drugs, along with genes that are biomarkers or potential therapeutic targets for many lung diseases, exhibited 24-h cyclic oscillations, suggesting an important role for such rhythms in regulating various aspects of the physiology and pathophysiology of lung. lung Microarray [1]
Protein Sequence
(Fasta)
MNTSCWKSIT QRPALPTAGP QQSAMTREGQ FREELGYDRM PTLERGRQDA GRQDTGSYTP 60
DTKPKDLQLT KRLPPCFSYK TWVFSVLMGS CLLVTSGFSL YLGNVFPSEM DYLRCAAGSC 120
IPSAIVSFAV GRRNVSAIPN FQILFVSTFA VTTTCLIWFG CKLILNPSAI NINFNLILLL 180
LLELLMAATV IISARSSEEP CKKKKGSISD GTNILDEVTF PARVLKSYSV VEVIAGVSAV 240
LGGVIALNVE EAVSGPHLSV TFFWILVACF PSAIASHVTA ECPSKCLVEV LITISSLTSP 300
LLFTASGYLS FSVMRIVEIF KDYPPDIKSY DVLLLLLLLL LLLQGGLNTG TAIQCVSFKV 360
SARLQAASWD SQSCPQERPA GEVVRSPLKE FDKEKAWRAV VVQMAQ 406
Sequence Source Uniprot/ENA
Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0016323--C:basolateral plasma membrane
GO:0005901--C:caveola
GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005769--C:early endosome
GO:0005783--C:endoplasmic reticulum
GO:0005768--C:endosome
GO:0016021--C:integral component of membrane
GO:0005764--C:lysosome
GO:0045121--C:membrane raft
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0055037--C:recycling endosome
GO:0032403--F:protein complex binding
GO:0008565--F:protein transporter activity
GO:0072584--P:caveolin-mediated endocytosis
GO:0071397--P:cellular response to cholesterol
GO:0032388--P:positive regulation of intracellular transport
GO:0051259--P:protein oligomerization
GO:0015031--P:protein transport
GO:0047484--P:regulation of response to osmotic stress
GO:0016192--P:vesicle-mediated transport

Interpro

IPR033280--Membrane_MLC1