| Tag |
Content |
| CGDB ID |
CGD-MuM-018411 |
| Uniprot Accession |
Q9D8Z2; Q9D8Z2; TRIA1_MOUSE; Q6LCG5
|
| Protein Name |
TP53-regulated inhibitor of apoptosis 1; Protein 15E1.1; WF-1; p53-inducible cell-survival factor; p53CSV |
| Gene Name |
Triap1; 15e1.1 |
| Genbank Protein ID |
NP_081209.1 |
| Genbank Nucleotide ID |
NM_026933.2 |
| Organism |
Mus musculus (Mouse) |
| NCBI Taxa ID |
10090 |
Circadian Information
|
| Evidence |
Phase |
Amplitude
(FOLD) |
Sentence |
Tissue/Cell |
Data type |
PMID |
| Peak |
Trough |
External
condition |
| High-throughput |
ZT 2 |
ZT 10 |
LD |
1.77 |
Mice are most sensitive to UVB-induced DNA damage in the epidermis at night. |
telogen epidermis |
Microarray |
[1] |
| High-throughput |
ZT 18 |
ZT 6 |
LD |
1.37 |
It is specifically the nutritional challenge, and not the development of obesity, that causes the reprogramming of the clock and the effects of diet on the clock are reversible. |
liver |
Microarray |
[1] |
| High-throughput |
ZT 0 |
ZT 12 |
LD |
1.74 |
This study provides an important chronobiological resource (www.wgpembroke.com/shiny/SCNseq/) and allows us to propose that transcriptional timing in the SCN is gating clock resetting mechanisms. |
SCN |
RNA-seq |
[1] |
|
| Description | Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis.(View all)Functional Description
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. |
Protein Sequence
(Fasta) |
MNSVGEACTD MKREYDQCFN RWFAEKFLKG DGSGDPCTDL FKRYQQCVQK AIKEKEIPIE 60
GLEFMGHGKE KPENSS 76Fasta Sequence
>CGD-MuM-018411|Q9D8Z2|TP53-regulated inhibitor of apoptosis 1|Mus musculus (Mouse)
MNSVGEACTDMKREYDQCFNRWFAEKFLKGDGSGDPCTDLFKRYQQCVQKAIKEKEIPIEGLEFMGHGKEKPENSS |
| Sequence Source |
Uniprot/ENA |
| Keyword |
KW-0007--Acetylation
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1015--Disulfide bond
KW-0445--Lipid transport
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0813--Transport
|
| Gene Ontology |
GO:0005758--C:mitochondrial intermembrane space
GO:0005739--C:mitochondrion
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0002039--F:p53 binding
GO:1990050--F:phosphatidic acid transporter activity
GO:0034644--P:cellular response to UV
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0043066--P:negative regulation of apoptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:1902166--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:0015914--P:phospholipid transport
GO:2001140--P:positive regulation of phospholipid transport
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0097035--P:regulation of membrane lipid distribution
|
| Interpro |
IPR007918--MDM35_apoptosis
|
| Pfam |
PF05254--UPF0203
|
