| Tag |
Content |
| CGDB ID |
CGD-MuM-014688 |
| Uniprot Accession |
Q541V2; Q541V2; Q541V2_MOUSE
|
| Protein Name |
Hermansky-Pudlak syndrome 4 homolog (Human), isoform CRA_b |
| Gene Name |
Hps4; mKIAA1667; mCG_128624 |
| Genbank Protein ID |
NP_619587.3; XP_006534893.1; XP_006534894.1; XP_006534895.1 |
| Genbank Nucleotide ID |
NM_138646.3; XM_006534830.2; XM_006534831.2; XM_006534832.2 |
| Organism |
Mus musculus (Mouse) |
| NCBI Taxa ID |
10090 |
Circadian Information
|
| Evidence |
Phase |
Amplitude
(FOLD) |
Sentence |
Tissue/Cell |
Data type |
PMID |
| Peak |
Trough |
External
condition |
| High-throughput |
CT 7 |
CT 18 |
DD2 |
2.60 |
Identified over 3,000 different transcripts in the mouse liver that cycle with a period length of approximately 24 hours. |
liver |
Microarray |
[1] |
| High-throughput |
ZT 6 |
ZT 18 |
LD |
1.31 |
It is specifically the nutritional challenge, and not the development of obesity, that causes the reprogramming of the clock and the effects of diet on the clock are reversible. |
liver |
Microarray |
[1] |
| High-throughput |
ZT 12 |
ZT 0 |
LD |
3.39 |
This study provides an important chronobiological resource (www.wgpembroke.com/shiny/SCNseq/) and allows us to propose that transcriptional timing in the SCN is gating clock resetting mechanisms. |
SCN |
RNA-seq |
[1] |
|
Protein Sequence
(Fasta) |
MATTTPPETK SAAWWNYFFL YDGSKVKGEG DPTRAGICYF YPPQTLLDQQ ELLCGQLAGV 60
VRCLWDLSGT PPMLIRMRNL KFAIRADGDY LWALGCGVEI SDASCRQFLD QLIGFFHFYM 120
GPVSLAYKSH PQEELSLQWD TSITQVLRST SESHRIFNAL WNLDRTKVEP LLLLKAALIL 180
QTCQRSPHVL AGCILYKGLI VNSQLLPSLT AKVLLHQTVP ADQRLPGAGA APQETGAALP 240
PDVQITSVFL SEEEVASLHE FPVEHETRLQ GSSVQYPPWD QSSPTQAEDA WASAAIPEPT 300
PHDGACPSGS GADERLPRLE QECAGPTGLC TTACGQGSGL SSRLQKELCL SREELDSSEM 360
HVSEAQEAFP PLPALGDLET LHSSHSAPTL PEDTAICSCL HPCPLERLPE SGRLGQLADL 420
PLTNGQTQVP GTDPLPSSMP VALPPQHPVG VEPSVEPYGN GAQESHSALP RSSRSPDSPG 480
PSPSADRTGF KPSPSGRHAG LVPMNLYTHS VNGLVLSLLA EETLLSDTAA IEEVYHSSLA 540
SLNGLEVHLK ETLPRDEASL TSSTYNFLHY DRIQSVLSAN LPLVTAPQDR RFLQAVNLMH 600
SDFALLPMLY EMTIRNASTA VYACSSPAQE TYFQQLAPTA RSSGFPNPQD CAFSLAGKAK 660
QKLLKHGVNL L 671Fasta Sequence
>CGD-MuM-014688|Q541V2|Hermansky-Pudlak syndrome 4 homolog (Human), isoform CRA_b|Mus musculus (Mouse)
MATTTPPETKSAAWWNYFFLYDGSKVKGEGDPTRAGICYFYPPQTLLDQQELLCGQLAGVVRCLWDLSGTPPMLIRMRNLKFAIRADGDYLWALGCGVEISDASCRQFLDQLIGFFHFYMGPVSLAYKSHPQEELSLQWDTSITQVLRSTSESHRIFNALWNLDRTKVEPLLLLKAALILQTCQRSPHVLAGCILYKGLIVNSQLLPSLTAKVLLHQTVPADQRLPGAGAAPQETGAALPPDVQITSVFLSEEEVASLHEFPVEHETRLQGSSVQYPPWDQSSPTQAEDAWASAAIPEPTPHDGACPSGSGADERLPRLEQECAGPTGLCTTACGQGSGLSSRLQKELCLSREELDSSEMHVSEAQEAFPPLPALGDLETLHSSHSAPTLPEDTAICSCLHPCPLERLPESGRLGQLADLPLTNGQTQVPGTDPLPSSMPVALPPQHPVGVEPSVEPYGNGAQESHSALPRSSRSPDSPGPSPSADRTGFKPSPSGRHAGLVPMNLYTHSVNGLVLSLLAEETLLSDTAAIEEVYHSSLASLNGLEVHLKETLPRDEASLTSSTYNFLHYDRIQSVLSANLPLVTAPQDRRFLQAVNLMHSDFALLPMLYEMTIRNASTAVYACSSPAQETYFQQLAPTARSSGFPNPQDCAFSLAGKAKQKLLKHGVNLL |
| Sequence Source |
Uniprot/ENA |
| Keyword |
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
|
| Gene Ontology |
GO:0031085--C:BLOC-3 complex
GO:0005764--C:lysosome
GO:0042470--C:melanosome
GO:0016020--C:membrane
GO:0042827--C:platelet dense granule
GO:0007040--P:lysosome organization
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0050821--P:protein stabilization
GO:0006605--P:protein targeting
|
| Interpro |
IPR026091--HPS4
|
